Voici une offre de post-doc concernant le marquage de biomolécules :
The Institut de Chimie Moléculaire de l’Université de Bourgogne (ICMUB), in Dijon (France), and especially Franck Denat’s group, is involved in the development of innovating systems for medical imaging techniques such as nuclear imaging (PET/SPECT), optical imaging (fluorescence) and magnetic imaging (MRI). The group is specialized in the synthesis of new fluorophores and new chelators (i.e. DOTA-like compounds), the characterization of their metal complexes (Cu-64, In-111, Ga-68, Zr-89), as well as their immobilization on biological vectors (peptides, antibodies,...) through innovative bioconjugation chemistry.
As part of a European program involving several academic and industrial partners, the ICMUB is now looking to recruit a Post-Doctoral Research Associate for 2 years (starting date: asap).
The project aims at studying the relationship between antibody/peptide concentration and the biological effects in target and non-target tissue in animal models, by PET imaging, in order to reduced attrition rate during the development of biologics.
The selected candidate will have in charge:
- the in vitro evaluation of the stability of new Zr-89 chelates in biological media;
- the labelling of monoclonal antibodies and peptides, with metal chelators and near-infra red fluorescent dyes, through site-specific strategies such as the enzymatic engineering of protein glycans, in order to produce chemically-defined protein conjugates;
- the purification and characterization of such imaging agents.
To be successful in this role, the candidate will need to have a passion for lab-work and experimentation. You will use your strong technical knowledge and a drive to deliver results, to contribute to the team’s mission of delivering in time, fully defined antibodies and peptides conjugate to our partners.
- PhD degree
- Fluency in English
- Proven track record in protein labelling: synthesis of imaging agents, ADC, …
- Hands on experience on purification and analysis of protein conjugates: HPLC/FPLC methods for SEC/IEC/RP chromatography; mass spectrometry (MALDI, ESI)
- Excellent written and oral communication skills
- Ability to adapt to rapid changes in projects priorities and meet aggressive timelines
- Committed to working in a collaborative manner within a European consortium
- Experience in organic synthesis and peptide chemistry
- Experience in radiochemistry (in particular labeling of peptides/proteins with radiometals
Prof Franck Denat,
phone: +33 3 80 39 61 15