Vous trouverez ci-dessous les détails d'une offre de post-doc chez Servier :
Drug induced liver injury (DILI) is the leading cause of acute liver failure and post-market withdrawals. Modeling clinically relevant preclinical tools is a major challenge for drug development, and mainly for DILI prediction. Various liver models are available but most of them lack longevity and tissue-level complexity limiting their utility in predictive toxicology. The three-dimensional (3D) cell printing technology has emerged as one of innovative technologies that may help to overcome these limitations.
The objective of this project is to establish and characterize a novel bio-printed human liver tissue with human hepatic cell lines and non parenchymental cells in a defined architecture.
One part of this work will be to set the bio-printing conditions including the ideal architecture and number/type of cells allowing a better prediction of hepatotoxicity. Histologic analysis will be performed on bio-printed liver tissue and the cellular organization will be studied by IHC. This latter technic could also be used to estimate the presence of enzymes of phase I&II and transporters.
Then, bio-printed liver tissues will be treated with a panel of DILI and non-DILI compounds to assess their functional activity (e.g. metabolism) and their capacity to predict toxicity.
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