Référence : UMR9002-SEVCHA-001
Lieu de travail : MONTPELLIER
Date de publication : lundi 20 août 2018
Type de contrat : CDD Scientifique
Durée du contrat : 30 mois
Date d'embauche prévue : 1 novembre 2018
Quotité de travail : Temps complet
Rémunération : 2500 euros brut mensuel
Niveau d'études souhaité : Doctorat
Expérience souhaitée : 1 à 4 années
A post-doc position in the Non-coding RNA, epigenetics and genome stability group is available. Our laboratory is mainly interested in dissecting the biogenesis and the role of Piwi-piRNA complex in Drosophila. We have demonstrated that the Argonaute Piwi protein is required during Drosophila embryonic development for the activation of piRNA clusters via the deposition of H3K9me3 repressive marks. Once established in the embryo, this epigenetic mark will be maintained in a Piwi-independent manner during the whole ovarian development. Which are the subunits of the multimeric protein complex involved in heterochromatin formation and which is the characteristic of the future heterochromatic sequences will be the main questions of the post-doc project.
Technically, the candidate will use standard molecular and biochemistry approaches (protein complex purifications, cell cultures). The candidate will perform proteomics, small RNA purification and bioinformatics analyses. The candidate will validate the data using Drosophila genetics.
We are seeking highly motivated candidate holding a PhD in Life Sciences. Experience in biochemistry and in molecular biology is mandatory. A solid background in Drosophila genetics, bioinformatics would be a plus. The candidate should have strong communication and organization skills, and be fluent in English.
Contexte de travail
A post-doc position is available in the Non-coding RNA, epigenetics and genome stability group at the Institute of Human Genetics in Montpellier. Our laboratory is mainly interested in understanding the role of non-coding RNAs and their associated complexes in heterochromatin formation in Drosophila.
More informations on the link below :